arirangtoday health2013.7.21---TXNIP基因延缓衰老预防癌症

arirangtoday health2013.7.21---TXNIP基因延缓衰老预防癌症
A group of Korean scientists thinks it has discovered a genetic link that could unlock the secret to preventing cancer and even slow aging. Our Paul Yi explains this groundbreaking research and what it means for the future of medicine. This three-dimensional image shows a scanned cross-section of human bone marrow, marking out the various types of stem cells in the body.
Hematopoietic stem cells, in particular, have been the focus of intense study here at the the Korea Research Institute of Bioscience & Biotechnology.
These special stem cells give rise to new red and white blood cells, making it a crucial component of the body's immune system. Dr. Jung Hai-young, lead researcher at the institute's Immunotherapy Research Center, says his team was able to identify a genetic mechanism that maintains this biological balance.
"During our research of the mechanisms that induce aging, we found that the TXNIP gene and a protein called p53 interact with each other. We were able to identify that this interaction plays a key role in anti-oxidization."
TXNIP is a gene that is typically found in hematopoietic stem cells and regulates the expression of the tumor-suppressing protein, p53. By working together, they inhibit and repair the damage from oxidative stress,... a natural build-up of toxins that can lead to cancer, heart failure and Alzheimer's disease.
In animal testing, mice that lacked the TXNIP gene died after just seven days, whereas the mice in the control group had normal life spans. Researchers found that the gene-deficient mice had up to 90 percent less hematopoietic cells and up to 40 percent more oxidative stress-related compounds.
The results confirmed that the TXNIP gene helps slow the aging of stem cells and prevents cancer development.
"We were able to identify the genes that play an important role in processes such as in the reduction of immune cells and blood cells. The results of this study will be used for future research in immune regulation, aging and cancer treatments.
The groundbreaking study was published online this month in the international scientific journal "Cell Metabolism," laying the foundation for future medical research.
Paul Yi, Arirang News

一组韩国科学家认为他们已经发现了一个遗传链接，可以预防癌症，甚至延缓衰老的秘密解锁。
我们的保罗毅解释这一开创性的研究和医学的未来意味着什么。此三维图象显示人骨髓扫描的横截面，标示出不同类型的干细胞在体内。
造血干细胞，尤其是这里的紧张学习的重点在韩国生物科学与生物技术研究所。 这些特殊的干细胞产生新的红，白血细胞，使人体的免疫系统的一个重要组成部分。 博士荣海年轻，研究所的免疫治疗研究中心首席研究员，他说，他的团队能够识别的遗传机制，保持这种生物的平衡。
“”的机制，诱导老化在我们的研究，我们发现TXNIP基因和蛋白质名为P53彼此交互。我们能够识别这种相互作用中起着关键作用，抗氧化。
TXNIP是一个基因，它通常见于造血干细胞和调节的肿瘤抑制蛋白，p53蛋白的表达。 他们一起工作，抑制和修复免受氧化应激的损伤，...一个自然的积聚，可导致癌症，心脏衰竭和阿尔茨海默氏病的毒素。
在动物试验中，TXNIP基因小鼠，缺乏短短七天后死亡，而对照组的小鼠正常寿命。 研究人员发现，基因缺陷的小鼠有90％较少的造血干细胞和高达40％的氧化应激相关化合物。 结果证实TXNIP基因有助于慢干细胞的老化，防止癌症的发展。
“我们能够以确定该基因的过程中，例如在降低的免疫细胞和血细胞中发挥重要的作用。将被用于本研究的结果，为今后的研究的免疫调节作用，老化和癌症治疗。
开创性的研究在线发表在国际科学期刊“细胞代谢本月，”为未来医学研究奠定了基础。
保罗·易，阿里郎新闻